Searching for Lodging Along Interstates

Google Hotel Finder used to allow you to draw a specific area on a map but that service has been shut down and integrated into Google Maps.

Google Maps may be your best bet, you can search for "hotel" then set your dates. You can drag through the map along the road you're looking at or you can zoom out and focus only on the results along the road you're looking at, you may need to click through several pages of results since google wont necessarily show them on the map if you're zoomed out really far.

There are apps for this.

For example, Android has the free iExit Interstate Exit Guide app which, in real time, locates where you are and shows upcoming exits and amenities.

Additionally, if you're not averse to print (or as a back-up or planner), the most comprehensive guide is Next Exit: The Most Complete Interstate Highway Guide Ever Printed (2016) by Mark Watson

The Waze and Map.me apps for smart phones access Open Street Map which you can also access in web browser. It shows many things, including hotels. Data is not complete of course.

Google maps and Apple maps also show such things, but are also not complete. A smartphone app and website WalkScore.com shows things on a map or in a list ordered by distance. None of them show everything, but in combination, you can get a lot of info.

I would use the map view, and zoom in on each intersection. When a hotel icon appears. click on it to get information, which usually includes links to reviews and to the hotel's website.

Also, many hotel/hostel booking websites have a search on map option. Often it takes a while to find and doesn't work well, but it might be worth a try. Of course, those sites only list hotels that can afford to pay for being listed.