Concerns with long-distance driving

You might want to consider a membership to a roadside assistance plan, which will at least give you a number to call for 24/7 repair services or towing should you have a problem during your trip.

A lot of wear and tear happens when you drive while the engine is still cold. On a long distance drive, your engine will be at its optimal temperature most of the time.

A lot of wear and tear happens when you accelerate and slow down, use the brakes, the clutch, etc. On a long distance drive, you might be two hours on the motorway without ever braking or shifting gears.

So, the wear and tear, and the chances of breaking down, are less than if you did the same distance 5 miles at a time over many weeks.

This may sound strange, but have you considered renting a car for the trip? Rentals are usually well maintained and a mid size car with unlimited miles will cost less than the cost of a tuneup.

In addition to the other answers I'd suggest planning for the contingency that you need to split the drive over 3 days instead of 2, if you find you are getting tired or making slower progress than expected.

So, know where you'd head if you had to break for the night after 6 or 8 hours instead of 10 (or sitting in an unexpected traffic jam for several hours).

Then you can adjust your plans if necessary and stop in a town with food and rest available, rather than finding out halfway across a mountain pass that your eyes won't stay open any longer.

[Technically, the question is about the vehicle, but I venture that a human being of good judgement would allow it.]

Not that it will actually help, but... you need to be aware that your reaction time will be dulled by about 2 to 1.5 (additional) seconds. [This is from personal experience, not science.]

Also (since I'm here)... if you are getting tired... I have found that annoying music is far less effective than enjoyable music; pick something that you want to sing along to. (This is not to be taken as explicit advice to push on when you are tired.)

More subjectively... I find that it is a sign of getting tired, that I am less able to stick to the speed limit effectively, and to follow my desired line on corners; I would not immediately take this as an indication to pull off the road, but certainly as a flag. If and when it gets worse, pull over! [Pardon me speaking strongly.] (I am speaking as a then-full-time driver; I do not know how it translates, for someone who does not normally drive for hours.)

I've driven my Opel Corsa 1.3 CDTi (I don't remember the exact year it was manufactured but it would've been in the early 2000s) that at that point in time already had a mileage of more than 250,000 KM (250 thousand kilometers) across Europe twice (from Croatia to Netherlands and back) which is 1420 KM each way without a problem. The car has always been properly maintained, the roads were in perfect condition, and I was traveling in the summertime. Furthermore, those were trips where I only took small brakes to refuel, eat and stretch my legs.

Like others have said, it's all about the condition. Planes can be 30 years old and more, but if they're properly maintained there's no reason to decommission them.

To answer your question, I wouldn't worry about it.

Aside from all the other good advice, keep an eye on the car's engine temperature gauge and plan to stop as soon as you can safely do so if it exceeds the normal temperature. Failure to do so will quickly destroy your car, or at least total it in the sense that it's economically impractical to repair unless you know how to do all the work yourself.

If you absolutely need to keep going for a while in a vehicle that's overheating because you don't feel safe where you are, turn the AC off and the heater on full blast. Depending on the cause of the overheating, this might be able to dissipate enough heat that you don't destroy your engine immediately.

Another possible failure mode (which I once experienced) on long trips is loss of transmission fluid due to seal failure. The likely symptom is feeling like the car barely speeds up when you press the accelerator. If this happens you want to stop and get a tow. I kept driving (topping off the transmission fluid again and again) and ended up needing a transmission rebuild (likely over $2500 in 2018 dollars) rather than just a seal replacement.

If you maintain your vehicle well and it's mechanically sound, then there shouldn't be any issues. My car is 13 years old. We've had it for 12 of those 13 years. I live in the central U.S. My car went over 100,000 miles (160,000 km) during the middle of a 4,000 mile (6,400 km) round-trip to the west coast. It went over 125,000 miles (200,000 km) during a 1,300 mile (2,000 km) round-trip to the east coast. It went over 150,000 miles (240,000 km) during a 1,000 mile (1,600 km) round-trip to New Orleans.

I currently have 185,000 miles (almost 300,000 km) on this car. It needs some suspension work, a new power steering pump, and new tires. With that work, I would have complete confidence in driving it on a similar trip.

There are two parts to the additional stress. First, running at real speed, i.e. 70-80 mph. . Second, sustained high power operation. Doing both for the first time will expose existing flaws in the car. So do these things early and often, well before the trip, to shake the bugs out of the car.

Western rural speed limits are 75-85, however it is rare for traffic to exceed that. Traffic is mostly trucks, and their fuel cost goes up a lot with speed.

Once your car is happily cruising and stable, it should be relatively stable. Just as aircraft rarely have a problem in cruise, constant speed cruising for a car is easy service. The only things which wear worse are tires and suspension.